Saturday, 16 December 2017

DrK's Brain Attack trial

Time is Brain, even in MS! 

How quickly should we treat MS? 

DrK makes the case for treating everyone as quickly as possible. Do you agree? Can you help us convince Biogen about the case for a Brain Attack Trial?


Friday, 15 December 2017

Blockade of Interleukin 17. Is it the Bees Knees?

At a meeting (At the Limits) recently a pair of prominent immunologists took exception, when I hinted that Blockade of Interleukin 17 has been perceived to have failed in MS, because of modest efficacy.

I was challenged on this. I replied I did not say it did not work, but countered that it was not much better than beta interferon. They said that it was not that it did not work, but that it was dropped for operational reasons. 

Operational Reasons. I wonder?. 
Did they simply really mean, it wasn't good enough? 


Thursday, 14 December 2017

Dying on your terms: is it possible?

The Australian state of Victoria has become became the country’s first to legalise assisted dying or suicide. Is dying a better euphemism? 


Wednesday, 13 December 2017

We need a new way to measure upper limb function in MS: can you help us?

As you may know, we at Barts-MS are passionate about the importance of upper limb function for people with MS. And our #ThinkHand campaign aims to increase awareness.

Part of this project is to develop a new way for people to record and measure their upper limb function. We currently work with Patient Reported Outcome Measures (PROMs), such as the ABILHAND, which is a questionnaire that patients are asked to complete at clinical visits.  Read more about that in a previous blog post.


Tuesday, 12 December 2017

Monday, 11 December 2017

Temperature dependence of impulse conduction in optic nerve axons

Thanks for the comments
We were grateful when a number of readers responded to our enquiry regarding temperature dependent symptoms in MS, and we learned more about how people cope with the symptoms. Following this conversation, I thought it worthwhile to draw attention to a paper we recently published, that suggests that there are functional differences between normal peripheral and central axons, and these differences provide a new view on temperature sensitivity.   

Education: What do antibodies do

You have full text access to this OnlineOpen article
Prospects from systems serology research
Kelly B. Arnold and Amy W. Chung
Version of Record online: 1 DEC 2017 | DOI: 10.1111/imm.12861

An internal cell signalling molecule found to support remyelination

Do you want to know about cell signalling and how the oligodendrocyte knows when to make myelin or not?


Sunday, 10 December 2017

Measuring Hand Function

Online monitoring of hand function. Are you up for doing the BRAIN test or will the cardboard 9HPT do the job? 



Saturday, 9 December 2017

Relapse without cell depletion in the blood

As you may be aware I have been banging on about the importance of B memory cells for most of the year, but it has been an uphill struggle to get this view accepted. 

However, response to therapy creates a powerful piece of insight that frankly can't be ignored. But I meet Ostriches ever day.